| FBXL5:一种维持细胞内铁稳态的泛素连接酶 |
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| 引用本文： | 郭晓强,丁卉,李会,李珍,段相林.FBXL5:一种维持细胞内铁稳态的泛素连接酶[J].生命的化学,2010(2). |
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| 作者姓名： | 郭晓强 丁卉 李会 李珍 段相林 |
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| 作者单位： | 河北师范大学生命科学院;解放军白求恩军医学院生化教研室; |
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| 基金项目： | 国家自然科学基金资助项目(38070265); 河北省自然基金项目(C2008000157)资助 |
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| 摘 要： | 细胞内铁稳态的维持主要通过铁调节蛋白(ironregulatory protein,IRP)与几种铁代谢基因如转铁蛋白受体和铁蛋白mRNA上铁应答元件结合来实现。铁不足可增加IRP2活性和含量,而铁过载则诱导了IRP2的泛素化和蛋白降解。F-盒蛋白FBXL5是一种铁和氧依赖的E3泛素连接酶,在铁和氧存在的情况下催化IRP2的泛素化,而缺铁或缺氧则造成FBXL5自身被泛素化修饰和随后的蛋白酶体降解。FBXL5铁调节功能的发现使人们对细胞内铁稳态的理解更为清晰。
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| 关 键 词： | 铁调节蛋白 细胞内铁稳态 FBXL5 泛素连接酶 |
FBXL5: a ubiquitin ligase for cell iron homeostasis |
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| Xiao-Qiang Guo,Hui Ding,Hui Li,Zhen Li,Xiang-Lin Duan College of Life,Hebei Normal University,Shijiazhuang ,China.FBXL5: a ubiquitin ligase for cell iron homeostasis[J].Chemistry of Life,2010(2). |
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| Authors: | Xiao-Qiang Guo Hui Ding Hui Li Zhen Li Xiang-Lin Duan College of Life Hebei Normal University Shijiazhuang China |
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| Institution: | Xiao-Qiang Guo1,2,Hui Ding1,Hui Li1,Zhen Li1,Xiang-Lin Duan1 1College of Life,Hebei Normal University,Shijiazhuang 050016,China,2Department of Biochemistry,Bethune Military Medical College,Shijiazhuang 050081 |
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| Abstract: | Cellular iron homeostasis is mainly maintained by iron regulatory protein (IRP) binding to iron-responsive elements (IREs) in mRNA of several iron metabolism genes such as transferrin receptor (TfR) and ferritin.The activity and level of IRP2 increase in case of iron deficiency,however,it is ubiquitinated and degraded under iron-repletion conditions.The F-box protein FBXL5 is one kind of iron- and oxygen-dependent E3 ubiquitin ligase.FBXL5 can catalyze IRP2 ubiquitination in the presence of iron and oxygen,... |
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| Keywords: | iron regulatory protein cellular iron homeostasis FBXL5 ubiquitin ligase |
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