Nucleation temperature‐controlled synthesis and in vitro toxicity evaluation of l‐cysteine‐capped Mn:ZnS quantum dots for intracellular imaging |
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| Authors: | Vivek Pandey Gajanan Pandey Vinay Kumar Tripathi Sapna Yadav Mohana Krishna Reddy Mudiam |
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| Institution: | 1. Analytical Chemistry Laboratory, Regulatory Toxicology Group, CSIR‐Indian Institute of Toxicology Research, Lucknow, India;2. Department of Applied Chemistry, Babasaheb Bhimrao Ambedkar University, Lucknow, India;3. Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR‐Indian Institute of Toxicology Research, Lucknow, India;4. Pesticide Toxicology, CSIR‐Indian Institute of Toxicology Research, Lucknow, India;5. Academy of Scientific and Innovative Research, Council of Scientific & Industrial Research, Lucknow, India |
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| Abstract: | Quantum dots (QDs), one of the fastest developing and most exciting fluorescent materials, have attracted increasing interest in bioimaging and biomedical applications. The long‐term stability and emission in the visible region of QDs have proved their applicability as a significant fluorophore in cell labelling. In this study, an attempt has been made to explore the efficacy of l ‐cysteine as a capping agent for Mn‐doped ZnS QD for intracellular imaging. A room temperature nucleation strategy was adopted to prepare non‐toxic, water‐dispersible and biocompatible Mn:ZnS QDs. Aqueous and room temperature QDs with l ‐cysteine as a capping agent were found to be non‐toxic even at a concentration of 1500 µg/mL and have wide applications in intracellular imaging. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | quantum dots bioimaging nucleation neuronal cells l‐cysteine |
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