Subcellular distribution of 2',5'-oligoadenylate synthetase in differentiating Friend leukemia cells |
| |
| Authors: | Nadir Mechti Elisabetta Affabris Gianna Romeo Bernard Lebleu |
| |
| Affiliation: | Laboratoire de Biochimie des Protéines, ERA CNRS 482, University of Montpellier II, Montpellier, France;Department of Virology, Istituto Superiore di Sanita, and Institute of Cellular and Developmental Biology, University of Rome, Rome, Italy |
| |
| Abstract: | The occurrence of distinct (2'-5')(A)n-synthetase activities has recently been documented in cytoplasmic and nuclear extracts of several interferon (IFN)-treated cell lines. Since a role has been proposed for (2'-5')(A)n synthetase in the control of cell growth and differentiation, we examined the subcellular distribution of (2'-5')(A)n-synthetase activity both in IFN-treated undifferentiated Friend leukemia cells (FLCs) and during dimethyl-sulfoxide (DMSO)-induced erythroid differentiation of FLCs. Both the nuclear and cytoplasmic (2'-5')(A)n activities were modulated to the same extent by IFNs and DMSO. No evidence for a causal relationship between enzyme activation and FLC differentiation was found. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
