Risk of Advanced Neoplasia in First-Degree Relatives with Colorectal Cancer: A Large Multicenter Cross-Sectional Study |
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Authors: | Enrique Quintero Marta Carrillo Maria-Liz Leoz Joaquin Cubiella Carla Gargallo Angel Lanas Luis Bujanda Antonio Z Gimeno-García Manuel Hernández-Guerra David Nicolás-Pérez Inmaculada Alonso-Abreu Juan Diego Morillas Francesc Balaguer Alfonso Muriel |
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Institution: | Enrique Quintero,Marta Carrillo,Maria-Liz Leoz,Joaquin Cubiella,Carla Gargallo,Angel Lanas,Luis Bujanda,Antonio Z. Gimeno-García,Manuel Hernández-Guerra,David Nicolás-Pérez,Inmaculada Alonso-Abreu,Juan Diego Morillas,Francesc Balaguer,Alfonso Muriel,on behalf of the Oncology Group of the Asociación Espa?ola de Gastroenterología (AEG) |
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Abstract: | BackgroundFirst-degree relatives (FDR) of patients with colorectal cancer have a higher risk of developing colorectal cancer than the general population. For this reason, screening guidelines recommend colonoscopy every 5 or 10 y, starting at the age of 40, depending on whether colorectal cancer in the index-case is diagnosed at <60 or ≥60 y, respectively. However, studies on the risk of neoplastic lesions are inconclusive. The aim of this study was to determine the risk of advanced neoplasia (three or more non-advanced adenomas, advanced adenoma, or invasive cancer) in FDR of patients with colorectal cancer compared to average-risk individuals (i.e., asymptomatic adults 50 to 69 y of age with no family history of colorectal cancer).ConclusionsIndividuals having two FDR with colorectal cancer showed an increased risk of advanced neoplasia compared to those with average-risk for colorectal cancer. Men had over 2-fold higher risk of advanced neoplasia than women, independent of family history. These data suggest that screening colonoscopy guidelines should be revised in the familial-risk population. |
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