Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane |
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| Authors: | Ban Shizuka Nakagawa Hidehiko Suzuki Takayoshi Miyata Naoki |
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| Institution: | Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. |
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| Abstract: | Oxidative stress affecting lipid membranes is considered to be closely related to cardiovascular disease and brain ischemia. In this study, we designed and synthesized membrane-localizing TEMPO derivatives and demonstrated that one of these synthesized probes, compound 1, localized and detected oxidative stress in the cell membrane in an endotoxic model of a mouse macrophage-like cell line. Compound 1 is therefore a potentially useful probe for evaluating oxidative stress at the cell membrane. |
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