Modeling of Actual Eukaryotic Control Gene Subnetworks Based on the Method of Generalized Threshold Models |
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Authors: | Tchuraev R N Galimzyanov A V |
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Institution: | (1) Institute of Biology, Ufa Research Center, Russian Academy of Sciences, Ufa, 450054, Russia |
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Abstract: | Mathematical and computational means are developed that take into consideration the specifics of control processes at the molecular level and allow one to obtain both qualitative and quantitative patterns of gene network dynamics. Using the method of generalized threshold models, models are constructed for the Arabidopsis thalianaflower morphogenesis control subsystem and gene subnetwork controlling the Drosophila melanogasterearly ontogeny. The dynamics of these systems are investigated: kinetic curves are computed for molecular components (RNA, proteins), possible modes of functioning and steady states of the nets are revealed and biologically interpreted. The models are shown to be adequate to the real processes. The effectiveness of the generalized threshold model method is evaluated in the analysis of the actual eukaryotic gene networks. |
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Keywords: | eukaryotic gene networks Drosophila melanogaster Arabidopsis thaliana method of generalized threshold models controlling and controlled subsystems equations molecular component dynamics |
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