Spray-Dried Cellulose Nanofibers as Novel Tablet Excipient |
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Authors: | Ruzica Kolakovic Leena Peltonen Timo Laaksonen Kaisa Putkisto Antti Laukkanen Jouni Hirvonen |
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Institution: | (1) Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), 00014 Helsinki, Finland;(2) VTT Technical Research Centre of Finland, P.O. Box 1000, 02044 VTT Espoo, Finland;(3) UPM Nanocenter, Tekniikantie 2C, 02150 Espoo, Finland |
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Abstract: | The purpose of this study was to evaluate the potential of cellulose nanofibers (also referred as microfibrillated cellulose,
nanocellulose, nanofibrillated, or nanofibrillar cellulose) as novel tabletting material. For this purpose, physical and mechanical
properties of spray-dried cellulose nanofibers (CNF) were examined, and results were compared to those of two commercial grades
of microcrystalline cellulose (MCC), Avicel PH101 and Avicel PH102, which are the most commonly and widely used direct compression
excipients. Chemically, MCC and CNF are almost identical, but their physical characteristics, like mechanical properties and
surface-to-volume ratio, differ remarkably. The novel material was characterized with respect to bulk and tapped as well as
true density, moisture content, and flow properties. Tablets made of CNF powder and its mixtures with MCC with or without
paracetamol as model compound were produced by direct compression and after wet granulation. The tensile strength of the tablets
made in a series of applied pressures was determined, and yield pressure values were calculated from the measurements. With
CNF, both wet granulation and direct compression were successful. During tablet compression, CNF particles were less prone
to permanent deformation and had less pronounced ductile characteristics. Disintegration and dissolution studies showed slightly
faster drug release from direct compression tablets with CNF, while wet granulated systems did not have any significant difference. |
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