| 南海中华小尖柳珊瑚中嘌呤和嘧啶类化合物的研究 |
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| 引用本文： | 王萍,漆淑华,黄丽思,贺飞,农旭华,孙玉林.南海中华小尖柳珊瑚中嘌呤和嘧啶类化合物的研究[J].天然产物研究与开发,2012,24(1):4-7. |
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| 作者姓名： | 王萍 漆淑华 黄丽思 贺飞 农旭华 孙玉林 |
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| 作者单位： | 1. 中国科学院南海海洋研究所,广州510301;中国科学院研究生院,北京100049
2. 中国科学院南海海洋研究所,广州,510301 |
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| 基金项目： | 国家自然科学基金课题(20872151,40976090);广东省自然科学基金项目(8151030101000020) |
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| 摘 要： | 对采自海南三亚的中华小尖柳珊瑚Muricella flexuosa的化学成分进行研究,采用反复硅胶柱色谱法、Sephadex LH-20柱色谱法及重结晶等手段对化合物进行分离和纯化,通过理化性质及光谱分析并结合文献对照,鉴定得到11个嘌呤、嘧啶类化合物:咖啡碱(1),1,7-二甲基次黄嘌呤(2),1-甲基次黄嘌呤(3),7,9-二甲基-6-氮甲基嘌呤-8-酮(4),7-甲基腺嘌呤(5),1,7-二甲基嘌呤-6,8-二酮(6),尿嘧啶(7),胸腺嘧啶(8)2,’-脱氧尿嘧啶核苷(9)2,’-脱氧胸腺嘧啶核苷(10),3-乙基-2’-脱氧尿嘧啶核苷(11)。其中化合物2～61,1为首次从该属中分离得到,化合物4和11为新的天然产物。
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| 关 键 词： | 中华小尖柳珊瑚Muricella flexuosa 化学成分 结构鉴定 嘌呤 嘧啶 |
Purine and Pyrimidine Analogues from the South China Sea Gorgonian Muricella flexuosa |
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| WANG Ping
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QI Shu-hua
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HUANG Li-si
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HE Fei
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NONG Xu-hua
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SUN Yun-lin.Purine and Pyrimidine Analogues from the South China Sea Gorgonian Muricella flexuosa[J].Natural Product Research and Development,2012,24(1):4-7. |
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| Authors: | WANG Ping QI Shu-hua HUANG Li-si HE Fei NONG Xu-hua SUN Yun-lin |
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| Institution: | WANG Ping1,2,QI Shu-hua1*,HUANG Li-si1,2,HE Fei1,NONG Xu-hua1,2,SUN Yun-lin1,2 1South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301; 2Graduate University of The Chinese Academy of Sciences,Beijing 100049,China |
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| Abstract: | Eleven compounds were isolated from the South China Sea gorgonian Muricella flexuosa by meanings of silica gel,Sephadex LH-20 column chromatography and recrystallization.Their structures were identified by physicochemical properties,spectroscopic analysis and comparison with the data of literatures.These 11 compounds were caffeine(1),1,7-diethylhypoxnathine(2),1-methylhypoxnathine(3),7,9-dimethy-6-(N-methyl)purine-8-one(4),7-ethyladenine(5),1,7-diethylpurine-6,8-dione(6),uracil(7),thymine(8),2′-deoxyuridine(9),2′-deoxythymidine(10),3-ethyl-2′-deoxythymidine(11).Compounds 2-6 and 11 were obtained from the genus Muricella for the first time,and 4 and 11 were isolated from nature for the first time. |
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| Keywords: | gorgonian Muricella flexuosa chemical constituent structure identification purine pyrimidine |
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