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Pergolide Presynaptically Inhibits Calcium-Stimulated Release of γ-Aminobutyric Acid |
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| Authors: | Kelly L. Drew Urban Ungerstedt |
| Affiliation: | Institute of Arctic Biology, University of Alaska, Fairbanks 99775-0180. |
| Abstract: | The release of gamma-aminobutyric acid (GABA) in rat dorsolateral striatum was studied using in vivo microdialysis. Dialysis was conducted 2 days after probe implantation in awake, freely moving rats using a modified Ringer solution. Calcium induced a reversible increase in GABA release that was abolished by tetrodotoxin but was only slightly attenuated by a maximally effective dose of pergolide, a D2 receptor agonist. It was thus concluded that pergolide inhibits calcium-stimulated release of GABA presynaptically by a mechanism distinct from that of tetrodotoxin. |
| Keywords: | In vivo microdialysis—D |