Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block |
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| Authors: | Cao Hongzhi Huang Shengshu Cheng Jiansong Li Yanhong Muthana Saddam Son Bryan Chen Xi |
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| Affiliation: | Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, United States |
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| Abstract: | The sialyl Lewis x tetrasaccharide with a propylamine aglycon was assembled by chemoselective glycosylation from a p-tolyl thioglycosyl donor obtained from an enzymatically synthesized sialodisaccharide. Combining the advantages of highly efficient enzymatic synthesis of sialoside building blocks, and diverse chemical glycosylation, this chemoenzymatic approach is practical for obtaining complex sialosides and their analogues. |
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| Keywords: | Sialyl Lewis x Sialoside Oligosaccharide Chemoenzymatic synthesis |
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