| 模拟微重力条件下大鼠肝细胞三维培养支架材料的筛选（简报） |
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| 引用本文： | 张守全,高淑静,江青艳,劳全林,冯定远.模拟微重力条件下大鼠肝细胞三维培养支架材料的筛选（简报）[J].实验生物学报,2004,37(1):67-71. |
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| 作者姓名： | 张守全 高淑静 江青艳 劳全林 冯定远 |
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| 摘 要： | 组织工程是一门新兴的边缘学科，它是利用体外培养的人体功能细胞与适当的细胞外基质或支架材料相结合，然后将其移植到体内病损部位以期达到修复目的。微重力组织工程(Microgravity Tissue Engineering)是近年来由美国空间生物技术研究人员开创的一个独特研究领域，其核心技术是
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| 关 键 词： | 模拟微重力 三维培养 肝细胞 大鼠 支架材料 细胞亲合性 |
Selection of scaffolds of rat hepatocytes in three-dimension culture under simulated microgravity] |
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| Shou Quan Zhang,Shu Jing Gao,Qing Yan Jiang,Quan Lin Lao,Ding Yuan Feng.Selection of scaffolds of rat hepatocytes in three-dimension culture under simulated microgravity][J].Acta Biologiae Experimentalis Sinica,2004,37(1):67-71. |
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| Authors: | Shou Quan Zhang Shu Jing Gao Qing Yan Jiang Quan Lin Lao Ding Yuan Feng |
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| Institution: | College of Animal Science, South China Agricultural University, Guangzhou 510642. |
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| Abstract: | In order to investigate the biocompatibility, degradation and inflammatory reactions of poly benzyl glutamate (PBLG), poly lactic-co-glycolic acid (PLGA) and fibrin gel used as the scaffolds co-cultured with the hepatocytes of rats under simulated microgravity conditions in rotating wall vessel bioreactor (RWVB). PLGA is low biocompatibility, PBLG is medium biocompatibility with rat hepatocytes. Fibrin gel is high biocompatibility, no toxic degradation and no inflammatory reactions. Fibrin gel can be used as three dimensional scaffolds of rat hepatocytes under simulated microgravity. |
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