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Effect of Haemopoietic Stem-Cell Proliferation Regulators On Early and Late Spleen Colony-Forming Cells
Authors:E. G. Wright  S. A. Lorimore  B. I. Lord
Affiliation:Department of Anatomy and Experimental Pathology, University of St Andrews, Fife, U.K.;Paterson Laboratories, Manchester, U.K.
Abstract:
An inhibitor and stimulator of CFU-s proliferation can be obtained from haemopoietic tissue containing, respectively, relatively quiescent CFU-s (e.g. normal bone marrow) and proliferating CFU-s (e.g. regenerating bone marrow). Their effects on the proliferative behaviour of steady-state and regenerating marrow CFU-s, which produce colonies 7, 10 and 12 days post-transplantation have been investigated. The results demonstrate changing sensitivities of CFU-s to inhibitor and stimulator as they progress through a developmental age structure. ‘Older’ CFU-s (producing early spleen colonies) are more sensitive to stimulator, ‘Younger’ CFU-s (producing late spleen colonies) are more sensitive to inhibitor.
Keywords:
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