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Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment
Authors:Lisa GM van Baarsen  Carla A Wijbrandts  François Rustenburg  Tineke Cantaert  Tineke CTM van der Pouw Kraan  Dominique L Baeten  Ben AC Dijkmans  Paul P Tak  Cornelis L Verweij
Affiliation:(1) Department of Pathology, VU University Medical Center, De Boelelaan 1118, 1081 Amsterdam, HZ, The Netherlands;(2) Current address: Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, AZ, The Netherlands;(3) Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, AZ, The Netherlands;(4) Department of Molecular Cell Biology & Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081 Amsterdam, BT, The Netherlands;(5) Department of Rheumatology, VU University Medical Center, De Boelelaan 1117, 1081 Amsterdam, HV, The Netherlands
Abstract:

Introduction  

Cross-regulation between TNF and type I IFN has been postulated to play an important role in autoimmune diseases. Therefore, we determined the effect of TNF blockade in rheumatoid arthritis (RA) on the type I IFN response gene activity in relation to clinical response.
Keywords:
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