Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation |
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| Authors: | Hong Sung-Yu Chung Kwang-Hoe You Hea-Jung Choi Ik Hwa Chae Mi Jin Han Ja-Young Jung Ok-Jai Kang Soo-Jung Ryu Chung-Kyu |
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| Institution: | College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea. |
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| Abstract: | A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole-4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs. |
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