Oligonucleotide aptamers against tyrosine kinase receptors: Prospect for anticancer applications期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Oligonucleotide aptamers against tyrosine kinase receptors: Prospect for anticancer applications

Authors:	Simona Camorani Elvira Crescenzi Monica Fedele Laura Cerchia

Affiliation:	Consiglio Nazionale delle Ricerche, Istituto per l''Endocrinologia e l''Oncologia Sperimentale “G. Salvatore” (IEOS), Via S. Pansini 5, 80131 Naples, Italy

Abstract:

Keywords:	2′-F-Py 2′-fluoro-pyrimidines 3D three-dimensional 3WJ three-way junction AMD age-related macular degeneration AuNPs gold nanoparticles BBB blood-brain barrier Bcl-2 B-cell lymphoma 2 BM bone marrow CCL2 chemokine C-C motif ligand 2 CXCL12 chemokine C-X-C motif ligand 12 dT deoxythymidine Dox doxorubicin ECD extracellular domain EGFR epidermal growth factor receptor EGFRwt EGFR wild-type GBM glioblastoma GSCs glioblastoma stem cells HAuNS hollow gold nanospheres HGF hepatocyte growth factor IGF insulin-like growth factor IR insulin receptor D dissociation-constant mAbs monoclonal antibodies MAPKs mitogen-activated protein kinases MED1 mediator subunit 1 miRNA/miR microRNA MSCs mesenchymal stem cells NK natural killer NPs nanoparticles NSCLC non-small cell lung cancer 3 methoxy PDGFs platelet-derived growth factors PDGFRα platelet-derived growth factor receptor α PDGFRβ platelet-derived growth factor receptor β PEG polyethylene glycol PI3K phosphatidylinositol 3-kinase PNPs polymeric nanoparticles PSMA prostate-specific membrane antigen Pu purines RTKs receptor tyrosine kinases SELEX systematic evolution of ligands by exponential enrichment siRNA small interfering RNA SPECT/CT single-photon emission computed tomography/computed tomography ss single-stranded TKIs tyrosine kinase inhibitors TME tumor microenvironment TNBC triple-negative breast cancer VEGF vascular endothelial growth factor VM vasculogenic mimicry Aptamer Cancer diagnosis Cancer therapy RTK SELEX Targeted delivery
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