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Lectin-induced apoptosis of tumour cells |
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| Authors: | Kim M; Rao MV; Tweardy DJ; Prakash M; Galili U; Gorelik E |
| Institution: | Pittsburgh Cancer Institute, University of Pittsburgh PA 15213 1Department of Pathology, University of Pittsburgh PA 15213 2Medicine, University of Pittsburgh PA 15213 3Department of Microbiology and Immunology, Medical College of Pennsylvania Philadelphia, PA 19129, USA |
| Abstract: | The mechanisms of cytotoxic activity of Griffonia simplicifolia1-B4 (GS1B4) and wheat germ agglutinin (WGA) lectins againstvarious murine tumour cell lines were studied. Tumour cellsthat lack lectin-binding carbohydrates were resistant to lysisby these lectins. However, YAC-1 cells that expressed GS1B4lectin-binding sites showed low sensitivity to lysis. To furtheranalyse the relative importance of cell surface carbohydratesin lectin cytotoxicity, BL6–8 melanoma cells, which donot express the |
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