PI LBEI and PI JHOU: two new alpha-1-antitrypsin alleles

Summary Two new variants of alpha-1-antitrypsin were found in a Chinese population by isoelectric focusing in polyacrylamide gel. They have been named Lbeijing (PI^*LBEI) and Jhouyao (PI^*JHOU) respectively. With the samples reduced and alkylated, both the variants were anodal to M1 and cathodal to L. Omitting the alkylation step, however, the relative mobilities of L and Jhouyao were altered. Under this condition, a characteristic of Jhouyao was revealed by isoelectric focusing in immobilized pH gradient 4.4–4.9, i.e., while its band 6 became anodal to L, band 4 was still cathodal to L.