Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer |
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Authors: | Lundin Eva Wirgin Isaac Lukanova Annekatrin Afanasyeva Yelena Krogh Vittorio Axelsson Tomas Hemminki Kari Clendenen Tess V Arslan Alan A Ohlson Nina Sieri Sabina Roy Nirmal Koenig Karen L Idahl Annika Berrino Franco Toniolo Paolo Hallmans Göran Försti Asta Muti Paola Lenner Per Shore Roy E Zeleniuch-Jacquotte Anne |
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Institution: | 2. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;3. Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;4. Pingtung Hospital, Department of Health, Executive Yuan, Pingtung, Taiwan;5. Department of Urology, Kaohsiung Municipal Ta‐Tung Hospital, Kaohsiung, Taiwan;11. Department of Pharmacy, China Medical University, Taichung, Taiwan;1. Department of Obstetrics and Gynecology, The Ottawa Hospital, University of Ottawa, Ottawa, ON |
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Abstract: | Background: The role of estrogen and progesterone in the development of endometrial cancer is well documented. Few studies have examined the association of genetic variants in sex hormone-related genes with endometrial cancer risk. Methods: We conducted a case-control study nested within three cohorts to examine the association of endometrial cancer risk with polymorphisms in hormone-related genes among 391 cases (92% postmenopausal at diagnosis) and 712 individually-matched controls. We also examined the association of these polymorphisms with circulating levels of sex hormones and SHBG in a cross-sectional analysis including 596 healthy postmenopausal women at blood donation (controls from this nested case-control study and from a nested case-control study of breast cancer in one of the three cohorts). Results: Adjusting for endometrial cancer risk factors, the A allele of rs4775936 in CYP19 was significantly associated (OR(per allele)=1.22, 95% CI=1.01-1.47, p(trend)=0.04), while the T allele of rs10046 was marginally associated with increased risk of endometrial cancer (OR(per allele)=1.20, 95% CI=0.99-1.45, p(trend)=0.06). PGR rs1042838 was also marginally associated with risk (OR(per allele)=1.25, 95% CI=0.96-1.61, p(trend)=0.09). No significant association was found for the other polymorphisms, i.e. CYP1B1 rs1800440 and rs1056836, UGT1A1 rs8175347, SHBG rs6259 and ESR1 rs2234693. Rs8175347 was significantly associated with postmenopausal levels of estradiol, free estradiol and estrone and rs6259 with SHBG and estradiol. Conclusion: Our findings support an association between genetic variants in CYP19, and possibly PGR, and risk of endometrial cancer. |
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