Comparison of the amino acid sequences of human protamines HP2 and HP3 and of intermediate basic nuclear proteins HPS1 and HPS2. Structural evidence that HPS1 and HPS2 are pro-protamines |
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| Authors: | P Sautière A Martinage D Bélaiche A Arkhis P Chevaillier |
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| Affiliation: | Unité Associée Centre National de la Recherche Scientifique No. 409, Institut de Recherches sur le Cancer, Lille, France. |
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| Abstract: | Two intermediate nuclear basic proteins HPS1 and HPS2 were isolated from human sperm. They were characterized by their electrophoretic mobility in acid-urea gels, their amino acid composition, and their peptide maps after digestion by endoproteinase Lys-C and by endoproteinase Glu-C. Their amino-terminal amino acid sequences have also been determined. The structural data thus obtained suggest that HPS1 and HPS2 are precursors of human protamines HP2 and HP3. |
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