Characterization of the <Emphasis Type="Italic">ompL1</Emphasis> gene of pathogenic <Emphasis Type="Italic">Leptospira species</Emphasis> in China and cross-immunogenicity of the OmpL1 protein |
| |
| Authors: | Haiyan Dong Ye Hu Feng Xue Dexter Sun David M Ojcius Yafei Mao Jie Yan |
| |
| Institution: | (1) Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, PR China;(2) Department of Medical Microbiology and Parasitology, Medical College of Zhejiang University, Hangzhou, Zhejiang, PR China;(3) Medical School of Jinhua Professional Technique College, Jinhua, Zhejiang, PR China;(4) New York Presbyterian Hospital & Hospital for Special Surgery Weill Medical College, Cornell University, New York, NY, USA;(5) School of Natural Sciences, University of California, Merced, CA, USA |
| |
| Abstract: | Background The usefulness of available vaccine and serological tests for leptospirosis is limited by the low cross-reactivity of antigens
from numerous serovars of pathogenic Leptospira spp. Identification of genus-specific protein antigens (GP-Ag) of Leptospira would be important for development of universal vaccines and serodiagnostic methods. OmpL1, a transmembrane porin of pathogenic
leptospires, was identified as a possible GP-Ag, but its sequence diversity and immune cross-reactivity among different serovars
of pathogenic leptospires remains largely unknown. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
