A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast <Emphasis Type="Italic">Saccharomyces cerevisiae</Emphasis> exposed to distinct antimicrobial peptides |
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| Authors: | Belén López-García Mónica Gandía Alberto Muñoz Lourdes Carmona Jose F Marcos |
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| Institution: | 1.Departamento de Ciencia de los Alimentos,Instituto de Agroquímica y Tecnología de Alimentos (IATA), CSIC,Burjassot,Spain;2.Departamento de Genética Molecular de Plantas,Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB,Barcelona,Spain;3.Fungal Cell Biology Group, Institute of Cell Biology (ICB),University of Edinburgh,Edinburgh,UK |
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| Abstract: | Background The mechanism of action of antimicrobial peptides (AMP) was initially correlated with peptide membrane permeation properties.
However, recent evidences indicate that action of a number of AMP is more complex and involves specific interactions at cell
envelopes or with intracellular targets. In this study, a genomic approach was undertaken on the model yeast Saccharomyces cerevisiae to characterize the antifungal effect of two unrelated AMP. |
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