| 丙型肝炎病毒非结构蛋白NS2的研究进展 |
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| 引用本文： | 龚巧玲,;王建,;贺福初. 丙型肝炎病毒非结构蛋白NS2的研究进展[J]. 生命科学, 2009, 21(1): 43-48 |
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| 作者姓名： | 龚巧玲, 王建, 贺福初 |
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| 作者单位： | 军事医学科学院放射与辐射医学研究所,北京蛋白质组研究中心,蛋白质组学国家重点实验室,北京102206;清华大学北京协和医学院一清华大学医学部,北京100005;军事医学科学院放射与辐射医学研究所,北京蛋白质组研究中心,蛋白质组学国家重点实验室,北京102206 |
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| 基金项目： | “863”计划（2006AA02A310）;“973”计划（2006CB910802）;国家自然科学基金创新研究群体（30621063） |
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| 摘 要： | 丙型肝炎病毒（hepatitis C virus,HCV）是一种严重危害人类健康的病原体,全球感染率约3％,中国普通人群抗HCV阳性率约3．2％。然而,到目前为止,HCV感染还没有有效的治疗方法。近年的研究发现,HCV非结构蛋白NS2在HCV感染中扮演着重要角色,具有许多重要功能。NS2可以在HCV病毒的包装过程中发挥其功能,还可调节宿主细胞的基因表达及凋亡过程。此外,NS2蛋自还可参与NS5A磷酸蛋白的高度磷酸化修饰过程及为感染性HCV病毒粒子产生所必需。本文综述近几年来关于NS2蛋白的研究进展。
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| 关 键 词： | 丙型肝炎病毒 非结构蛋白NS2 细胞周期 细胞凋亡 |
Advance in the research of the nonstructural protein NS2 of hepatitis C virus |
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| Affiliation: | GONG Qiao-ling, WANG Jian, HE Fu-chu (1. State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China; 2. Peking Union Medical College, Tsinghua University, Beijing 100005, China) |
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| Abstract: | Hepatitis C virus （HCV） is a major etiologic agent of non-A, non-B hepatitis, which seriously impairs human health. Estimate from WHO places the number of HCV-infected individuals at 170 million, representing nearly 3% of the world＇s population. Anti-HCV positive rate of healthy people in China is 3.2%. However, up to now, there is neither vaccine nor efficient therapy drug available. In recent years, the study of HCV found that non-structural protein NS2 plays an important role in HCV infection. For example, NS2 has a dual function in the HCV replication cycle by acting both as a protease and an essential assembly cofactor, regulate the host cell gene expression and apoptosis, participate in the NS5A protein excessive phosphorylation modification pro- cess and is essential for production of infectious virus. This paper reviews on the progress of the study of NS2 protein ifi the past few years. |
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| Keywords: | HCV NS2 cell apotosis cell cycle |
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