Loss of dendritic spines in Alzheimer's disease |
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| Authors: | K H el Hachimi J F Foncin |
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| Affiliation: | Division Montyon, H?pital de la Salpêtrière, Paris. |
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| Abstract: | Neurones from five patients with Alzheimer's disease were studied semi-quantitatively on Golgi impregnated samples of cerebral cortex. They showed a dramatic reduction in dendritic spine number of pyramidal and non-pyramidal cells of all neocortical layers, as compared with control samples matched for age. Dendritic spine loss could be an initial phenomenon in Alzheimer's disease pathology. |
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