Comparison between ambulatory measurement of effective thermal conductivity and laser Doppler flowmetry method to assess skin microcirculatory activity |
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| Institution: | 1. Biomedical Sensors Group, Nanotechnologies Institute of Lyon, INSA-Lyon, 20, avenue Albert-Einstein, 69621 Villeurbanne cedex, France;2. Centre scientifique et technique du bâtiment, 44300 Nantes, France;1. School of Computer Science and Technology, Xidian University, Xi’an 710071, Shaanxi, China;2. The Space Science and Engineering Center, University of Wisconsin-Madison, Madison, USA;3. Centre Ingnierie et Sant, Ecole Nationale Suprieure des Mines, 42023 Saint-Etienne, France;1. Univ. Nice Sophia Antipolis, CNRS, LJAD, UMR 7351, 06100 Nice, France;2. CCSE, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd. MS 50A-1148, 94720 Berkeley, CA, USA;3. Department of Physical Electronics, Faculty of Science, Masaryk University, Kotlá?ská 2, 611 37 Brno, Czech Republic;4. CNRS, UPR 288 Laboratoire EM2C, Grande Voie des Vignes, 92295 Châtenay-Malabry, France;5. Ecole Centrale Paris, Grande Voie des Vignes, 92295 Châtenay-Malabry Cedex, France;6. Fédération de Mathématiques de l''Ecole Centrale Paris, FR CNRS 3487, France;1. Masaryk University, Faculty of Medicine, Department of Biophysics, Kamenice 3, 62500 Brno, Czech Republic;2. University Hospital Brno, Department of Radiology, Jihlavska 20, Brno, Czech Republic;1. Department of Mechanical Engineering, University of Bath, Bath BA2 7AY, UK;2. Université de Toulouse, INPT, UPS, IMFT (Institut de Mécanique des Fluides de Toulouse), Allé Camille Soula, F-31400 Toulouse, France |
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| Abstract: | The main objective of this paper was to assess the performance of the ambulatory device μHematron to measure indirectly skin blood flow relative to the well-established Laser Doppler flowmetry method. The μHematron device is dedicated to the non-invasive measurement of effective thermal conductivity of living tissues, based on the thermal clearance method. Its major advantage is its ambulatory functionality, as available methods for evaluation of microcirculatory activity are non-ambulatory methods. An experiment was conducted on ten healthy women exposed for one hour in three different thermal environments (22 °C, 25 °C and 30 °C). Skin microcirculatory activity was analyzed after an acclimatization period of 30 minutes. The time between each exposure was at least one hour. Performances of the μHematron device were assessed and a comparative study with a laser Doppler perfusion monitor (LDPM) was performed. Good correlation coefficients between the two devices (r = 0.71 at T1 = 22 °C, r = 0.77 at T2 = 25 °C and r = 0.83 at T3 = 30 °C) were obtained while the LDPM signal was filtered by a low pass filter (0.1 Hz). These results showed that continuous monitoring of effective thermal conductivity was possible in neutral and warm ambiences. Then, the μHematron device could be considered as a complementary tool to Doppler techniques for the investigation of skin blood flow, when ambulatory conditions are required. |
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| Keywords: | Ambulatory device Effective thermal conductivity Thermal clearance Microcirculatory activity Non-invasive sensor Laser Doppler flowmetry |
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