Expression of estrogen receptors,androgen receptor and steroid receptor coactivator-3 is negatively correlated to the differentiation of astrocytic tumors |
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| Institution: | 1. Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing 400038, China;2. Cadet Brigade, Third Military Medical University, Chongqing 400038, China;1. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of Pharmacology & Neurobiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Velenjak, Tehran, Iran;4. Department of Medical Physiology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran;1. Department of Neurosurgery, Keio University, School of Medicine, Tokyo, Japan;2. Department of Pathology, Keio University, School of Medicine, Tokyo, Japan;3. Department of Neurosurgery, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan;4. Department of Neurosurgery, Tokyo Saiseikai Central Hospital, Tokyo, Japan;5. Department of Neurosurgery, Saitama City Hospital, Saitama, Japan;6. Department of Neurosurgery, Eiju General Hospital, Tokyo, Japan;7. Department of Neurosurgery, Tokyo Metropolitan Police Hospital, Tokyo, Japan;8. Department of Neurosurgery, Tokyo Medical University, Tokyo, Japan;1. Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland;2. Piekary Medical Centre, Department of General Surgery, Municipal Hospital in Piekary Śląskie, Piekary Śląskie, Poland;3. Health Care Centre Euro-Med Bytom, Bytom, Poland;1. College of Life Science, Liaoning Normal University, Dalian 116081, China;2. Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;3. State Key Laboratory of Genetic Engineering, College of Life Science, Fudan University, Shanghai 200433, China;4. Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116000, China;1. Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill;2. Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill;1. Centro Oceanográfico de Murcia, Instituto Español de Oceanografía (IEO), Carretera de la Azohía s/n, Puerto de Mazarrón, 30860 Murcia, Spain;2. Institute of Marine Biology and Genetics, Hellenic Center for Marine Research, Crete, Greece;3. Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, 30100 Murcia, Spain |
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| Abstract: | Astrocytic tumors are the most common primary brain tumors. It has been reported that androgen receptor (AR), estrogen receptors alpha (ERα) and beta (ERβ) and their coactivator SRC-1 and SRC-3 are involved in the regulation of the growth and development of many tumors, but their expression profiles and significances in the astrocytic tumors remain largely unknown. In this study, the expression of AR, ERs, and SRCs, and the possible roles of them in astrocytic neoplasm were evaluated and compared to normal brain tissues by nickel-intensified immunohistochemistry with tissue microarrays. The results showed that there were no age- or gender-differences regarding to the levels of these receptors or coactivators in astrocytic or normal brain tissues. In the high-grade astrocytic tissue, the levels of AR, ERs and SRC-3 were significantly decreased when compared to the low-grade astrocytic tissues, but the levels of SRC-1 remain unchanged. Correlation analysis revealed that the levels of AR, ERs and SRC-3 were negatively correlated to tumor differentiation, and the levels of SRC-3 were positively correlated to that of ERα. Furthermore, the decreased levels of SRC-3 were associated with an increase of ERβ in astrocytic tumors when compared to that of normal brain tissues. These above results indicate a combination of decreased expression of ERs, AR and SRC-3 but not SRC-1 may be involved in the tumorigenesis of gliomas, ERα/SRC-3 axis may play central role in the regulation these tumors. |
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| Keywords: | Astrocytomas Glioblastoma Androgen receptor Estrogen receptor Steroid receptor coactivator-1 Steroid receptor coactivator-3 |
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