Trypanosoma brucei: renal pathology in rabbits |
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| Authors: | C A Facer E A Molland A B Gray G C Jenkins |
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| Institution: | 1. Department of Haematology The London Hospital Medical College, Turner Street, London E1 2AD, England, U.K.;2. Department of Morbid Anatomy, The London Hospital Medical College, Turner Street, London E1 2AD, England, U.K. |
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| Abstract: | Rabbits experimentally infected with Trypanosoma brucei S42 develop two significant renal lesions: an early proliferative glomerulonephritis associated with glomerular deposits of IgG, IgM, and β1C laid down in a granular pattern in the glomerular capillary wall as revealed by immunofluorescence, and tubular atrophy with changes in enzyme activity of proximal tubule cells occurring late in infection. It is suggested that the two lesions could have a different aetiology. The glomerular changes result from deposition of soluble trypanosome immune complexes, whereas the tubular changes are typical of tissue ischemia. Trypanosomiasis in the rabbit could be a valuable model for studies of the pathogenesis of renal damage in Rhodesiense sleeping sickness. |
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| Keywords: | Hemoflagellate Parasitic protozoa Rabbits Kidney Histopathology Electron microscopy Histochemistry Immune complexes Sleeping sickness model PCT proximal convoluted tubule PC pars convoluta PR pars recta (PCT) TAL thin ascendng limb DCT distal convoluted tubule G glomerulus F fibrin/fibrinogen |
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