Modulation of the surface antigens of Salmonella-phagocytized U937 cells]

In this study, modulation of the surface antigens of Salmonella enteritidis-phagocytized U937 cells and morphology of the bacteria in these cells were analyzed by the indirect immunofluorescence technique. The results are as follows: (1) Morphological studies revealed that the bacteria phagocytized by the U937 cells were transformed to a small coccoid form. (2) The expression of CD14 antigen was observed 24 to 48 h after phagocytosis. (3) The levels of CD11b and CD23 antigens were clearly enhanced 48 h after phagocytosis. (4) No modulation of HLA-class II (DR, DQ and DP) antigens was observed after phagocytosis.