Enhanced efficiency of excision repair of non-replicated UV-damaged E. coli DNA |
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| Affiliation: | 1. Department of Pathology, College of Basic Medical Sciences and First Affiliated Hospital, China Medical University, Shenyang, PR China;2. Neurosurgery, The First Affiliated Hospital, China Medical University, Shenyang, PR China;1. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;2. Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran;3. Department of Medical Genetics, Tabriz University of Medical Sciences, Tabriz, Iran;4. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;5. Division of Hematology and Transfusion Medicine, Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;1. Department of Reproductive Medicine, Maternal and Child Care Center of Qinhuangdao, Qinhuangdao, 066000, China;2. Clinical Department, Qinhuangdao Mental Health Center, Qinhuangdao, 066000, China;3. School of Public Health, North China University of Science and Technology, Tangshan, 063210, China;4. Department of Ultrasonics, Maternal and Child Care Center of Qinhuangdao, Qinhuangdao, 066000, China;1. Saint-Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg 199034, Russia;2. Devyatykh Institute of Chemistry of High-Purity Substances, 49 Tropinina Str, Nizhny Novgorod 603950, Russia |
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| Abstract: | The efficiency of excision repair of UV-damaged E. coli DNA is enhanced when DNA replication is temporarily blocked. This block, in the presence and absence of excision repair, was obtained in a strain of E. coli, thermosensitive for DNA replication and its excision-deficient derivative. It is suggested that the regulation of DNA synthesis plays an important role in excision repair. |
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