Effects of estradiol and prolactin on steroid receptor levels in 7,12-dimethylbenz(a)anthracene-induced mammary tumors and uterus in the rat. |
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| Authors: | J Asselin F Labrie |
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| Affiliation: | 1. Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan;2. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA;3. Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA;4. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA;1. Administration, Hospital of the University of Pennsylvania, Philadelphia, PA;2. Department of Biobehavioral Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA;3. Department of Nursing, Hospital of the University of Pennsylvania, Philadelphia, PA;4. Penn Medicine Center for Health Equity Advancement, University of Pennsylvania Health System and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA |
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| Abstract: | In order to eliminate changes of pituitary hormone secretion secondary to treatment and be able to assess the direct effect of 17β-estradiol and prolactin at the level of hormone-dependent mammary tumors induced in the rat by 7,12-dimethylbenz(a)anthracene (DMBA), the effects of the two hormones on steroid receptor levels were investigated in hypophysectomized-ovariectomized animals. Treatment with prolactin alone led to tumor estrogen receptor levels higher than those found after estrogen administration. When the level of progesterone receptors was measured as parameter of estrogen action, it was found that combined treatment with prolactin and 17β-estradiol led to levels much higher than those found after individual hormone treatment. Tissue specificity of this interaction between prolactin and 17β-estradiol is indicated by the absence of effect of prolactin on the estrogen-induced stimulation of the progesterone receptor in uterine tissue. These data demonstrate the direct stimulatory effect of prolactin on estrogen receptor levels in DMBA-induced mammary carcinoma and indicate the central role of this pituitary hormone as modulator of estrogen action and growth of DMBA-induced mammary tumors. |
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