Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression,but little interleukin-22 and interleukin-23R expression |
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| Authors: | Leigh D Church Andrew D Filer Esther Hidalgo Katherine A Howlett Andrew MC Thomas Stephen Rapecki Dagmar Scheel-Toellner Christopher D Buckley Karim Raza |
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| Institution: | (1) Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, B15 2TT Edgbaston, Birmingham, UK;(2) Sandwell and West Birmingham Hospitals NHS Trust, Dudley Road, B18 7QH Birmingham, UK;(3) The Royal Orthopaedic Hospital, Bristol Road South, B31 2AP Northfield, Birmingham, UK;(4) UCB, 208 Bath Road, SL1 3WE Slough, Berkshire, UK |
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| Abstract: | Introduction Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to systematically
analyse the phenotype, cytokine profile and frequency of interleukin-17 (IL-17) producing CD4-positive T cells in mononuclear
cells isolated from peripheral blood, synovial fluid and synovial tissue of RA patients with established disease, and to correlate
cell frequencies with disease activity. |
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