| microRNA在急性淋巴细胞白血病中的作用 |
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| 引用本文： | 王梓,李善妮,刘静. microRNA在急性淋巴细胞白血病中的作用[J]. 生命科学研究, 2012, 16(2): 172-180 |
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| 作者姓名： | 王梓 李善妮 刘静 |
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| 作者单位： | 中南大学生物科学与技术学院 中国湖南长沙410013 |
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| 基金项目： | 国家自然科学基金资助项目，中央高校基本科研业务费资助项目，新疆生物资源基因工程重点实验室开放课题 |
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| 摘 要： | MicroRNAs(miRNAs)是一类非编码小RNA分子,其通过降解mRNAs或抑制mRNAs翻译来负调控基因表达并可能调控着几乎每一个细胞生理进程.急性淋巴细胞白血病(ALL)是儿童时期最常见的血液肿瘤,miRNA的异常表达谱对于ALL的发病机制与临床应用有至关重要的作用,因此miRNAs已迅速成为ALL潜在的治疗靶点.
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| 关 键 词： | 急性淋巴细胞白血病(ALL) microRNA 细胞因子 |
Functions of microRNA in Acute Lymphoblastic Leukemia |
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| WANG Zi , LI Shan-ni , LIU Jing. Functions of microRNA in Acute Lymphoblastic Leukemia[J]. Life Science Research, 2012, 16(2): 172-180 |
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| Authors: | WANG Zi LI Shan-ni LIU Jing |
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| Affiliation: | (Molecular Biology Research Center,School of Biological Science and Technology,Central South University,Changsha 410013,Hunan,China) |
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| Abstract: | MicroRNAs(miRNAs) are small noncoding RNA molecules that negatively regulate gene expres-sion through degradation or translational repression of their targeted mRNAs.It is likely that almost every cellular process is regulated by them.Acute lymphoblastic leukemia(ALL) is the most common hematologic tumor of pediatric age,aberrant miRNA expression profile can play a vital role in the pathogenesis of ALL and clinical applications of ALL,thus miRNAs have rapidly emerged as potential targets for therapeutics. |
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| Keywords: | acute lymphoblastic leukemia(ALL) microRNA cytokine |
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