Single-cell analysis of lambda immunity regulation |
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| Authors: | Baek Kristoffer Svenningsen Sine Eisen Harvey Sneppen Kim Brown Stanley |
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| Institution: | Department of Molecular Cell Biology, University of Copenhagen, ?ster Farimagsgade 2A, DK-1353, K, Copenhagen, Denmark. |
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| Abstract: | We have examined expression of the lambdacI operon in single cells via a rex Colon, two colons gfp substitution. Although average fluorescence agreed with expectations for expression of lambda-repressor, fluorescence fluctuated greatly from cell-to-cell. Fluctuations in repressor concentration are not predicted by previous models and are tolerated in part by a regulatory response to DNA damage. |
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| Keywords: | bacteriophage lambda repressor GFP single-cell analyses |
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