HBI-8000诱导成人T细胞白血病/淋巴瘤的细胞凋亡与Bim和NLRP3活化的相关性

本研究通过评估HBI-8000对日本ATL患者ATL细胞系和原代细胞的作用,来研究HBI-8000诱导成人T细胞白血病/淋巴瘤的细胞凋亡与Bim和NLRP3活化的相关性。选取若干侵袭型ATL患者作为研究对象,口服新型HBI-8000,跟踪并分析药物效果。研究表明,在大多情况下,HBI-8000在原代ATL细胞和细胞系中诱导细胞凋亡。Bim活化、NLR族、NLRP3炎症体通道对HBI-8000诱导ATL细胞死亡具有重大作用。实验为临床研究HBI-8000对ATL患者的疗效提供了理论基础。NLRP3可用于癌症新型治疗策略研究,但对ATL细胞死亡的作用仍有待验证。

Relationship between Apoptosis and BIM and NLRP3 Activation in Adult T-cell Leukemia/lymphoma Induced by HBI-8000

To investigate the role of HBI-8000 in ATL cell lines and primary cells in ATL in Japan to study the correlation between apoptosis of HBI-8000 induced adult T-cell leukemia/lymphoma and BIM and NLRP3 activation,a number of invasive ATL patients were selected as subjects,and new HBI-8000 were used to track and analyze the drug effects.In most cases,HBI-8000 induced cell apoptosis in the primary ATL cells and cell lines.BIM activation,NLR and NLRP3 inflammatory channels have significant effects on the HBI-8000 induced death of ATL cells.The experimental results provide a theoretical basis for the clinical study of HBI-8000 in patients with ATL.NLRP3 can be used in the study of new therapeutic strategies for cancer,but the role of ATL cell death remains to be validated.