Microbial transformations of cardioglycosides |
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| Authors: | Ján Fuska Bohumil Proksa Alžbeta Khandlová Mária Šturdíková |
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| Affiliation: | (1) Department of Biochemical Technology, Faculty of Chemistry, Slovak Technical University, Jánska 1, 81237 Bratislava, Czechoslovakia;(2) Institute of Chemistry, Slovak Academiy of Sciences, Dúbravská 9, 84238 Bratislava, Czechoslovakia |
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| Abstract: | Summary Penicillium vermiculatum deglycosylated lanatosid C to acetyldigoxin and Arthrobacter citreus deacetylated the latter to digoxin. Both reactions were carried out in a short time with high yields. Lanatosid A was transformed by P. vermiculatum simultaneously to acetyldigitoxin and digitoxin. A. citreus transformed lanatosid A directly to digitoxin and lanatosid C to digoxin, but the reactions took a long time and the yields were low. |
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