Antinociceptive and Met-enkephalin releasing effects of tachykinins and substance P fragments |
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| Authors: | J R Naranjo A Arnedo M C De Felipe J Del Rio |
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| Affiliation: | 1. Tasmanian Institute of Law Enforcement Studies (TILES), University of Tasmania, Private Bag 22, Hobart, TAS 7001, Australia;2. Chemical & Physical Sciences Group, Victoria Police Forensic Services Department, 31 Forensic Drive, Macleod, VIC 3085, Australia;3. Faculty of Law, University of Tasmania, Private Bag 89, Hobart, TAS 7001, Australia;4. Office of the Chief Forensic Scientist, Victoria Police Forensic Services Department, 31 Forensic Drive, Macleod, VIC 3085, Australia;5. Centre for Applied Psychology, University of Canberra, University Drive, Bruce, ACT 2601, Australia;1. Department of Computational Sciences, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India;2. Department of Computer Science & Engineering, University College of Engineering, Punjabi University, Patiala, Punjab, India;3. Department of Computer Science & Engineering, Thapar Institute of Engineering and Technology, Patiala, Punjab, India;4. Department of Information Technology, University Institute of Engineering and Technology, Panjab University, Chandigarh, India;1. Ecole des Sciences Criminelles, University of Lausanne, Building Batochime, 1015 Lausanne, Switzerland;2. University of Derby, School of Human Sciences, College of Science and Engineering, Kedleston Rd, Derby DE22 1GB, United Kingdom;3. University of Technology Sydney, Centre for Forensic Science, PO Box 123, Broadway, NSW 2007, Australia |
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| Abstract: | ![]()
Substance P (SP), physalaemin, SP4-11, SP5-11 and the SP5-11 analog DiMe-C7 induce an antinociceptive effect in rats after intraventricular administration. Other tachykinins and the N-terminal fragments of SP are inactive. All antinociceptive peptides increase the Met-enkephalin efflux from slices of rat periaqueductal gray matter and their antinociceptive potency is correlated with their capacity to release Met-enkephalin. The results, discussed in the light of current theories on different tachykinin receptors, suggest that the SP-P receptor subtype may be involved in the control of noxious stimulation elicited by SP at supraspinal levels. |
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