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Subcellular distribution of sulfated glucuronyl glycolipids in human peripheral motor and sensory nerves
Authors:Dr. Robert K. Yu  Hiide Yoshino  Masanaga Yamawaki  Jun E. Yoshino  Toshio Ariga
Affiliation:(1) Department of Psychology, Program of Neuroscience, Colgate University, Hamilton, N.Y., USA;(2) Department of Biochemistry and Molecular Biophysics Medical College of Virginia, Virginia Commonwealth University, 23298-0614 Richmond, VA, USA
Abstract:Sulfated glucuronyl glycolipids (SGGL) have been implicated as important target antigens in patients with demyelinating polyneuropathy and IgM paraproteinemia. Sulfated glucuronyl paragloboside (SGPG), a major species of SGGL, was identified in the subcellular fractions of human peripheral motor and sensory nerves using a simple and quantitative method. SGPG was found to be concentrated in the myelin-enriched fractions of both motor and sensory nerves (1.3±0.3 and 1.5±0.4 µg/mg protein, respectively), whereas its concentration was 0.9±0.2 and 1.8±0.6 µg/mg protein in the axolemma-enriched fractions of motor and sensory nerves, respectively. Our finding that SGPG is more abundant in the human sensory nerve axolemma-enriched fraction may account for the clinical and pathological observations that the lesions are more heavily concentrated in the sensory nerve than in other parts of the nerve tissues in this disorder.
Keywords:Sulfated glucuronyl glycolipids  Motor and sensory nerve  Myelin  Axolemma  HNK-1  Polyneuropathy  IgM paraprotein
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