Towards the Development of Hemerythrin-Based Blood Substitutes |
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| Authors: | Augustin C Mot Alina Roman Iulia Lupan Jr" target="_blank">Donald M KurtzJr Radu Silaghi-Dumitrescu |
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| Institution: | (1) Department of Chemistry and Chemical Engineering, “Babes-Bolyai” University, 11 Arany Janos str, Cluj-Napoca, 400028, Romania;(2) Department of Biology, “Babes-Bolyai” University, 11 Arany Janos str, Cluj-Napoca, 400028, Romania;(3) Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-0698, USA; |
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| Abstract: | Hemerythrin is proposed as an alternative to hemoglobin-based blood substitutes. In contrast to hemoglobin, hemerythrin exhibits
negligible reactivity towards oxidative and nitrosative stress agents (peroxide, nitric oxide, nitrite). Protocols for attachment
of polyethylene glycol and glutaraldehyde cross-linking of Hr are described. These derivatizations appear to have favorable
effects on O2 affinity and autoxidation rates for use in blood substitutes. Based on lessons learned from hemoglobin-based blood substitutes,
these derivatizations should also help limit extravasation and antigenicity of a hemerythrin-based blood substitute. |
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