Dietary subacute zinc deficiency and potassium metabolism |
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Authors: | Jacobus P Van Wouwe Marcel Veldhuizen |
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Institution: | (1) Department of Pediatrics, Drechtsteden Hospital “Jacobus”, Langeweg 336, 3331 LZ Zwijndrecht, the Netherlands;(2) Department of Radiochemistry, Interfaculty Reactor Institute, Delft University of Technology, Delft, the Netherlands |
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Abstract: | In a controlled animal experiment the effects of dietary subacute Zn deficiency on growth, Zn concentration, and tissue 42-K
distribution were studied. Growth retardation caused lower body weight because both skeletal and heart muscle showed a reduction
in cell mass. Zn concentrations were reduced in most tissues, however, they remained unaltered in heart muscle. 42-K activity
increased in skeletal muscle and pancreas. We hypothesize the latter reflects the organs rate of metabolism, inducing the
exocrine pancreas to increase Zn absorption; in skeletal muscle it may induce also alterations in cell potentiation, causing
restless behavior. As suggested by the calculated specific K activity (Bq/mol), the K uptake was highest in liver and bone,
high in pancreas and skeletal muscle and low in heart muscle. The latter suggests K retention in heart muscle. Specific activity
in plasma and jejunum remained unaltered: K status and absorption seem unaffected. Zn deficiency causes different 42-K activities
in the various tissues, that respond by alterations in K metabolism without the induction of K deficiency. |
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Keywords: | Dietary subacute Zn deficiency tissue Zn concentration K status tissue 42-K activity plasma erythrocytes tissue cell mass liver pancreas bone skeletal muscle heart muscle proximal jejunum |
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