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A model of a myelinated nerve axon: threshold behaviour and propagation
Authors:P Grindrod  B D Sleeman
Institution:(1) Department of Mathematical Sciences, University of Dundee, DD1 4HN Dundee, UK;(2) Present address: Mathematical Institute, University of Oxford, Oxford, UK
Abstract:A model of a myelinated nerve axon is developed on the basis of FitzHugh-Nagumo dynamics under the assumption that the nodes of Ranvier are of small but finite width. It is shown that a periodic excited state may not exist if the width of the nodes is too small and the leakage across the myelin sheath is too great. The propagation of a super threshold pulse is prevented in the absence of nodes. Global stability of the resting equilibrium state is investigated as well as the propagation of ldquowave frontrdquo, type solutions.
Keywords:Myelinated nerve axons  Nodes of Ranvier  FitzHugh-Nagumo dynamics  Threshold behaviour  Global stability  Wave fronts
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