Aeromonas salmonicida toxin AexT has a Rho family GTPase-activating protein domain |
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| Authors: | Litvak Yael Selinger Zvi |
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| Affiliation: | Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 Israel. |
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| Abstract: | The N terminus of the Aeromonas salmonicida ADP-ribosylating toxin AexT displays in vitro GTPase-activating protein (GAP) activity for Rac1, CDC42, and RhoA. HeLa cells transfected with the AexT N terminus exhibit rounding and actin disordering. We propose that the Aeromonas salmonicida AexT toxin is a novel member of the growing family of bacterial RhoGAPs. |
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