Thermodynamics of ABC transporters |
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Authors: | Xuejun C Zhang Lei Han Yan Zhao |
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Institution: | National Laboratory of Macromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
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Abstract: | ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the conformational changes following substrate binding remain to be elucidated. Here, we present our thermodynamic analysis for both ABC importers and exporters, and introduce the two new concepts of differential-binding energy and elastic conformational energy into the discussion.We hope that the structural analysis of ABC transporters will henceforth take thermodynamic aspects of transport mechanisms into account as well. |
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Keywords: | ABC transporters differential-binding energy energy-coupling elastic conformational energy |
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