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Immunochemical studies of organ and tumor lipids: IX. Configuration of the carbohydrate residues in cytolipin H
Affiliation:1. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA;1. Department of Pathology, San Giovanni Bosco Hospital, 10154 Turin, Italy;2. FISABIO Foundation, 46020, Valencia, Spain;3. Department of Health Sciences, European University of Valencia, 46023, Valencia, Spain;4. Department of Pathology, Cruces University Hospital, 48903 Barakaldo, Bizkaia, Spain;5. Biocruces-Bizkaia Institute, 48903 Barakaldo, Bizkaia, Spain;1. European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands;2. Division of Oncology, Department of Translational Medicine, University of Eastern Piedmont, Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy;1. Department of Molecular and Translational Medicine, University of Brescia, Italy;2. Italian Consortium for Biotechnology (CIB), Unity of Brescia, Italy
Abstract:The reaction between cytolipin H and antitumor serum is specifically inhibited by lactose. Cellobiose and d-galactose are ineffective. These observations provide strong evidence that the configuration of the glucose and galactose residues in cytolipin H have the configuration of the disaccharide 4-0-β-d-galactopyranosyl-d-glucopyranose (lactose).
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