The mouse Fc receptor for IgG (Ly-17) : molecular cloning and specificity |
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Authors: | P Mark Hogarth Margaret L Hibbs Lisa Bonadonna Bernadette M Scott Ewa Witort Geoffrey A Pietersz Ian F C McKenzie |
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Institution: | (1) Research Centre for Cancer and Transplantation, University of Melbourne, Grattan St., 3052 Parkville, Australia |
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Abstract: | A cDNA clone encoding the mouse Ly-17+ Fc receptor for IgG, isolated from a myelomonocytic cell line, was sequenced and expression of mRNA and the functional FcR investigated. The receptor is a 301 amino acid transmembrane glycoprotein with two homologous extracellular domains that are also homologous to members of the Ig superfamily. The receptor has four sites of N-linked glycosylation and a long 94 amino acid cytoplasmic tail. Northern analysis, immune complex binding, and serological studies demonstrate that the receptor encoded by the cDNA clone binds mouse IgG1/2b and rabbit IgG complexes. |
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