APHE-3, a spore-associated antibiotic of Streptomyces griseocarneus NCIMB 40447 |
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| Authors: | R Cruz M E Arias J Soliveri |
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| Institution: | (1) Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Alcalá. 28871-Alcalá de Henares, Madrid, Spain e-mail: mpsoliveri@microb.alcala.es Tel.: +34-91-8854634 Fax: +34-91-8854623, ES |
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| Abstract: | Solid cultures of the producing strain grown on Bennett medium develop abundant mycelium and intense sporulation. Under these
conditions biosynthesis of APHE antibiotics (APHE-1 to -3) is accomplished. Further studies show that APHE-3 is basically
produced during spore formation and mostly present in spores, while APHE-1 and APHE-2 are the predominant antibiotics in the
mycelium. APHE compounds are present in almost all streptomycetes tested, indicating a possible role in the life cycle of
these microorganisms.
Received: 19 July 1999 / Received revision: 22 October 1999 / Accepted: 22 October 1999 |
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