Inhibition of aggregation of human platelets by 8,15-dihydroperoxides of 5,9,11,13-eicosatetraenoic and 9,11,13-eicosatrienoic acids |
| |
Authors: | GS Bild SG Bhat B Axelrod PG Iatridis |
| |
Institution: | Department of Biochemistry Purdue University West Lafayette, Indiana 47907 USA;Department of Physiology Northwest Center for Medical Education Indiana University School of Medicine Gary, Indiana 46408 USA |
| |
Abstract: | The dihydroperoxy derivative of arachidonic acid, 8,15-dihydroperoxy-5,9,11,13-eicosatetraenoic acid, at
, is an effective inhibitor of the aggregation of human blood platelets, induced by ADP, epinephrine and collagen. The nature of the effect is time dependent. If ADP is added 60 sec after the inhibitor, the first phase of aggregation occurs but the second phase is suppressed. When the time is prolonged to 240 sec, the first phase of aggregation is almost completely eliminated. The corresponding dihydroxy derivative is without effect on aggregation. The corresponding dihydroperoxy derivative obtained from 8,11,14-eicosatrienoic acid is also an effective inhibitor. |
| |
Keywords: | To whom all requests for reprints may be sent |
本文献已被 ScienceDirect 等数据库收录! |
|