Clubbed thiazoles by MAOS: a novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer's disease |
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| Authors: | Shiradkar Mahendra Ramesh Akula Kalyan Chakravarthy Dasari Varaprasad Baru Vijayakumar Chiningiri Bhoomeshwar Gandhi Santosh Kaur Ranjit |
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| Affiliation: | Dr. Reddys Laboratories, 7-1-27 Ameerpet, Hyderabad 16, Andhra Pradesh, India. rrshiradkar@rediffmail.com |
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| Abstract: | A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease. |
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