Enhancement of imaging depth in turbid media using a wide area detector |
| |
| Authors: | Viera Crosignani Alexander S Dvornikov Enrico Gratton |
| |
| Institution: | Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II Building, Irvine, CA 92697‐2715, USA |
| |
| Abstract: | The depth of two‐photon fluorescence imaging in turbid media can be significantly enhanced by the use of the here described fluorescence detection method that allows to efficiently collect scattered fluorescence photons from a wide area of the turbid sample. By using this detector we were able to perform imaging of turbid samples, simulating brain tissue, at depths up to 3 mm, where the two‐photon induced fluorescence signal is too weak to be detected by means used in conventional two‐photon microscopy. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) |
| |
| Keywords: | two‐photon microscopy turbid media multiple scattering imaging depth |
|
|
