New thermodynamic characterization and transition mechanism of DNA duplex formation. |
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| Authors: | P Wu N Sugimoto |
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| Affiliation: | High Technology Research Center, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan. |
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| Abstract: | A new transition mechanism of DNA duplex association was proposed and a segregated transition model (STM) was further derived. The experimental results in various molar ratios showed that the duplex association transition is imperfect and the thermodynamic properties and self-transition behavior of single strands exert a significant influence on DNA duplex formation. |
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