CC类趋化因子亚家族与心肌梗死的研究进展

CC类趋化因子亚家族是趋化因子家族中成员最多、研究最广泛的一大类细胞因子，其主要功能参与炎症细胞激活、迁移、粘附等病理生理过程。大量研究表明，CC类趋化因子亚家族成员参与了心肌梗死后病理过程的各个阶段。其中研究最为深入的为单核细胞趋化蛋白-1（monocyte chemoattractant protein-1，MCP-1）及其受体CC趋化因子受体2（CC chemokine receptor 2，CCR2），在心肌梗死后炎症期、增殖期及疤痕愈合期都发挥了重要作用从而影响梗死后心室重构。近年来，CC类趋化因子亚家族其他成员亦被逐渐揭示参与了心肌梗死的发展。本文结合以往大量文献将对CC类趋化因子亚家族在心肌梗死各个阶段中尤其是梗死后各期对于心室重构的影响进行综述，以期为今后的实验研究提供方向及疾病的预防和治疗提供药物靶点。

The Roles of CC Chemokine in Myocardial Infarction

The CC chemokines is the largest and most widely studied group of chemokines,which play a critical role in inflammatory leukocyte locomotion ,trafficking and adhesion. The chemokine cc subfamily are involed in the pathogenesis of myocardial infarction. Monocyte chemoattractant protein-1 (MCP-1) and its receptor CC Chemokine receptor 2 (CCR2) ,as most-study chemokine,play an important role in post-infarction inflammation, proliferation and scar formation, thus affecting ventricular remodeling after myocardial infarction.In recent years, other members of the CC chemokines have been gradually revealed to be involved in the development of myocardial infarction. This article reviews the role of CC chemokines in various stages of myocardial infarction, especially the effects on ventricular remodeling after myocardial infarction, in order to provide direction for future experimental research and novel strategies in the treatment of patients with myocardial infarction disease.