多酚干扰细菌群体感应研究进展*

多酚化合物是人类日常饮食中一类典型的天然产物,具有干扰分子信号通路、影响肠道菌群组成和保护人体肠道健康的功能。针对不同微生物群体感应(quorum sensing,QS)系统,多酚能够干扰细菌生物膜的形成和微生物致病性。介绍多酚的类型、来源和含量,总结多酚对多种QS相关表型,如菌体运动性、黏附性、生物膜形成和毒力因子的释放等具有的干扰作用,以及一些常见多酚对典型病原体的干扰作用,提出基于多酚的QS干扰在未来疾病治疗中面临的主要挑战。

Research Progress on Polyphenol-based Quorum Sensing Interfering

Polyphenols, a typical class of natural products in our daily diet, have functions of interfering with molecular signaling pathways, affecting the composition of gut microbiota, and protecting human health. Biofilm formation and microbial pathogenicity can be interfered by various polyphenols targeting different microbial quorum sensing (QS) systems, which provides a theoretical basis for the clinical applications of polyphenols. However, the complexity of polyphenol-based interference involves multifarious compounds, various microorganisms and intricate microbial phenotypes. First, a brief summary of types, sources, and amounts of polyphenols is introduced, including flavonoids, phenolic acids, stilbene, lignans, and others based on the number of phenolic rings and structural elements. Then the polyphenol-based interference targeting diverse QS-relevant phenotypes is summarized, including microbial motility, microbial adhesion, biofilm formation, and the release of virulence factors. Furthermore, various interference effects of some common polyphenols on the typical pathogens are summarized to contribute to potential applications. Finally, some key challenges and general perspectives on polyphenol-based interference for various future therapeutic applications are identified.